The Skull was once the greatest driver in the F-MAX Grand Prix, a competition that predates the coming of F-ZERO by some 200 years. Thanks to the inexplicable powers of science and black magic, he has returned to this world to compete once again. With his remarkable technique and decision-making powers, he now has a chance to extend his legacy into a new generation.

Antonio was the right-hand man of Samurai Goroh, but Goroh betrayed and abandoned him into the hands of the Galactic Space Allies. After his release, he became a solo bandit, and now his only purpose in life is to have his revenge on Goroh, ideally in front of millions of fans on the F-ZERO circuit.

Beastman became a beast hunter after a nasty encounter with a gigantic crocodile on the planet White. After surviving the ordeal, he decided that he wanted to protect people from such dangerous creatures. He is actually quite shy and in order to keep his bashful nature from being discovered, he adorned himself in the imposing outfit of a dinosaur. Before long, due to his heroic deeds and growing popularity, he became known as the Beastman. Having dealt with all the beasts on his own planet, he entered the F-ZERO Grand Prix for promotional reasons. There, he met Bio Rex for the first time, and knowing the creature was competing, he made a vow to protect the other pilots and crowd from such a dangerous beast.

Leon is from the war-torn planet of Zou, where he lost both of his parents during the big war 12 years ago. As the planet suffered through the aftereffects of the war, it was decided that one F-ZERO machine should be sent to the Grand Prix with Leon as its pilot: a symbol of hope for the ailing planet. Leon has a great track record in the F-ZERO races as a result of his well-balanced abilities, and he desperately wishes to become a champion in order to save the children of Zou from poverty.

Super Arrow is a superhero who defends peace on Earth. He entered the last F-ZERO race to chase his old enemy, Zoda. At the time, Super Arrow had never driven before, so he had to hurriedly register for an F-ZERO license just so that he could enter the race. Even so, he managed to race competitively by utilizing his superpowers. Zoda has entered the race again, and Super Arrow must do all he can to stop him and end his reign of terror. He is known for his relentlessly unforgiving attitude toward criminals, but when it comes to his wife, Mrs. Arrow, he's as docile as a puppy.

Mrs. Arrow strives to defend her husband, Super Arrow, in and out of the home. She entered the F-ZERO race to assist her husband, who had no previous experience as a pilot. An F-ZERO circuit model before marriage, she was the first former circuit model to compete as a pilot.

On the planet Huckmine, the Furikake people have an odd custom - they pair up with a partner as soon as they're born and do everything together. The intelligent Gomar is very short and envies the strength of Shioh, while Shioh is a tall creature who admires Gomar greatly and depends entirely on his decision-making. This peculiar pair work together, deftly manipulating their F-ZERO machine built for two. However, these two partners who have been together as long as they can remember - will both marry next year, thereby undergoing a partner change. This event has given rise to many rumors about this F-ZERO Grand Prix being their last together.

People call Neelsen "Ironman Silver". Despite holding the record for most F-ZERO races entered by a single pilot, he has yet to win a Grand Prix. He turns 99 next year and is debating retirement, but he also considers it a good possibility that he'll continue his race career even after he turns 100. Silver loves the old-school machines, and he's become quite crotchety in his old age. He often criticizes the newfangled machines that other pilots are using.